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SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL ACTIVITIES OF Ni(II)- AND Cu(II)-COMPLEXES OF N-PYRAZOLYLPROPANAMIDE 

Adane Kassa

Debre Markos University, College of Natural and Computational Science, Department of Chemistry

 Authors email:adanekss97@gmail.com
 

Accepted  27 January 2015

The ligand N-pyrazolylpropanamide and two biologically active complexes of Ni⁺² and Cu⁺² with N-pyrazolylpropanamide have been synthesized and characterized. The synthesized ligand, metal salts and its complexes have been screened for their antimicrobial activities against two species of bacteria (Bacillus subtillis and Shigella) by agar diffusion method. The results showed that the metal complexes are more active than the ligand and metal salts alone against these bacterial species. In addition, the biological activity of the Cu⁺² complex is more active than the Ni⁺² complex against these same bacterial species.

Key words: N-pyrazolylpropanamide, transition metal complexes, antimicrobialactivity, Bacillus subtillis, Shigella, agar

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November: Vol. 2(1) pp.24-32

ISSN 2476-8340

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Abstract

Palgo Journal of Medicine and Medical Science

© Palgo Journals 2015